A marine biologist heads for Port Amanzi in Africa after his friend, Mark DeSantis, is supposedly a victim of a fatal shark attack. DeSantis had been conducting research on a series of shark attacks in the area prior to his death and now his friend, along with DeSantis' sister, takes up the research and finds that the sharks may not be the only threat in Port Amanzi.

While working in a dam in Africa, the American hydraulic engineer Tom Newman brings his family to spend a couple of days in the Leopard's Rest Lodge. His fourteen year-old daughter Jessica is having friction with her stepmother Amy since she does not accept the divorce of her parents. On the next morning, Amy, Jessica and her brother David go in a game drive with a ranger while Tom goes to the dam. While driving off-road, David asks the ranger to stop the jeep to go to the "toilet", and unexpectedly they are attacked by a group of starving lions that kill and eat the ranger. Amy, Jessica and David are trapped in the jeep and stalked by the wild lions. When Tom returns to the hotel and finds that his family has not returned from the game, he asks for help to the experienced hunter and guide Crawford and together they seek Tom's family.